Fei Wang ^†,‡, Xue-Lian Cheng ^‡, Ya-Ju Li ^‡, Song Shi ^‡, and Ji-Kai Liu ^*,†,‡

^† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences,  Kunming 650204, People’s Republic of China

^‡ BioBioPha Co., Ltd., Kunming 650204, People’s Republic of China

Abstract

Six new ent-pimarane diterpenoids, namely, ent-14,16-epoxy-8-pimarene-3,15R-diol (1), 7-hydroxydarutigenol (2),  9-hydroxydarutigenol (3), 16-O-acetyldarutigenol (4), 15,16-di-O-acetyldarutoside (5), and 16-O-acetyldarutoside (6),  were isolated from the ethanol extract of Siegesbeckia orientalis. Their structures were elucidated on the basis of  spectroscopic studies, and the absolute configuration of 1 was established by the modified Mosher’s method. Furthermore,  the structure of ent-12,16-epoxy-8-pimarene-2R,15,19-triol, recently isolated from the same plant, should be revised  as ent-14,16-epoxy-8-pimarene-2R,15R,19-triol (10).

文章链接：https://pubs.acs.org/doi/abs/10.1021/np900449r