Yuan Gao ^†,‡,§ , Gang-Qiang Wang ^†, Kun Wei ^†, Ping Hai ^‡, Fei Wang ^†,‡, and Ji-Kai Liu ^*

^† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China,

^‡ BioBioPha Co. Ltd., Kunming 650201,

^§ People's Republic of China, and Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Abstract

(±)-Guajadial B (1), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from  Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive analysis of NMR spectra and confirmed by  biomimetic synthesis in a domino three-component coupling reaction. 

文章链接：https://pubs.acs.org/doi/pdf/10.1021/ol302849v