Yuan Gao ^a,b , Ai-Lin Yu ^a , Gen-Tao Li ^c , Ping Hai ^a , Yan Li ^c , Ji-Kai Liu ^c,*, , Fei Wang ^a,*

^a BioBioPha Co., Ltd., Kunming 650201, People's Republic of China
^b Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China 

^c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

Abstract

Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1–5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.

文章链接：https://sciencedirect.xilesou.top/science/article/abs/pii/S0367326X15300976