Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, Nat. Prod. Bioprospect., 2016, 6: 233–237. | 西力原创成果

Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, Nat. Prod. Bioprospect., 2016, 6: 233–237.

发布时间：2019-08-02 阅读数：3457 来源：原创

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Xiang-Mei Li . Xian-Jun Jiang . Ku Yang . Li-Xia Wang . Shi-Zhen Wen . Fei Wang

Received: 3 September 2016 / Accepted: 8 September 2016 / Published online: 19 September 2016

Abstract

Four hitherto unknown prenylated coumarins, namely 6’’-O-β-D-apiofuranosylapterin (1), 4’-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC₅₀ values ranging from 15.9 to 23.2 μM.

文章链接：https://link.springer.xilesou.top/article/10.1007/s13659-016-0107-5

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