Ping Hai, Shi-Zhen Wen, Yan Li, Yuan Gao, Xian-Jun Jiang & Fei Wang

Received: 26 November 2013 / Accepted: 12 January 2014 / Published online: 19 February 2014 

© The Author(s) 2014. This article is published with open access at Springerlink.com

Abstract

Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.

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