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- Deoxyelephantopin Induces Apoptosis in HepG2 Cells via Oxidative Stress, NF-κB Inhibition and Mitochondrial Dysfunction. Biofactors, 2017, 43: 63–72.
- Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int. J. Mol. Sci., 2016, 17: 1199.
- Sterol Methyl Oxidases Affect Embryo Development via Auxin-Associated Mechanisms. Plant Physiol., 2016, 171: 468–482.
- Comparison of Two Exploratory Data Analysis Methods for Classification of Phyllanthus Chemical Fingerprint: Unsupervised vs. Supervised Pattern Recognition Technologies. Anal. Bioanal. Chem., 2015, 407: 1389–1401.
- Concurrent Quantification and Comparative Pharmacokinetic Analysis of Bioactive Compounds in the Herba Ephedrae-Semen Armeniacae Amarum Herb Pair. J. Pharm. Biomed. Anal., 2015, 109: 67–73.
Palmitic Acid and Ergosta-7,22-dien-3-ol Contribute to the Apoptotic Effect and Cell Cycle Arrest of an Extract from Marthasterias glacialis L. in Neuroblastoma Cells. Mar. Drugs, 2014, 12: 54–68.
We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a concentration-dependent way, the SH-SY5Y cell line being more susceptible. Cell cycle arrest was observed, an effect induced by the sterol, ergosta-7,22-dien-3-ol, present in the extract. Morphological evaluation of treated cells showed the advent of lipid droplets and chromatin condensation compatible with apoptosis, which was confirmed by the evaluation of caspase-3 and -9 activities. Palmitic acid was the main compound responsible for this apoptotic effect by a ceramide-independent mechanism that involved endoplasmic reticulum (ER)-stress with upregulation of CCAAT/-enhancer-binding protein homologous protein (CHOP).