- Dissection of Patulin Biosynthesis, Spatial Control and Regulation Mechanism in Penicillium expansum. Environ. Microbiol., 2019.
- Synthesizing Ginsenoside Rh2 in Saccharomyces Cerevisiae Cell Factory at High-Efficiency. Cell Discov., 2019, 5: 5.
- OcUGT1-Catalyzed Glucosylation of Sulfuretin Yields Ten Glucosides. Catalysts, 2018, 8: 416.
- Boosting 11-Oxo-β-amyrin and Glycyrrhetinic Acid Synthesis in Saccharomyces Cerevisiae via Pairing Novel Oxidation and Reduction System from Legume Plants. Metab. Eng., 2018, 45: 43–50.
- Cytochrome P450 Promiscuity Leads to a Bifurcating Biosynthetic Pathway for Tanshinones. New Phytol., 2016, 210: 525–534.
- Identification of an Oleanane-type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity. Mol. Pharmacol., 2018, 93: 63–72.
Palmitic Acid and Ergosta-7,22-dien-3-ol Contribute to the Apoptotic Effect and Cell Cycle Arrest of an Extract from Marthasterias glacialis L. in Neuroblastoma Cells. Mar. Drugs, 2014, 12: 54–68.
We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a concentration-dependent way, the SH-SY5Y cell line being more susceptible. Cell cycle arrest was observed, an effect induced by the sterol, ergosta-7,22-dien-3-ol, present in the extract. Morphological evaluation of treated cells showed the advent of lipid droplets and chromatin condensation compatible with apoptosis, which was confirmed by the evaluation of caspase-3 and -9 activities. Palmitic acid was the main compound responsible for this apoptotic effect by a ceramide-independent mechanism that involved endoplasmic reticulum (ER)-stress with upregulation of CCAAT/-enhancer-binding protein homologous protein (CHOP).